Michael Seringhaus
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LYSE, LYSE BABY
(cover of Vanilla Ice: Ice Ice Baby)

© 2001-2006 Michael Seringhaus / Riddlin' / PABACAS

 

Yo, PhD – let’s mix it.

Alright stop, grab some yeast and a test tube,
Stick it in buffer that’s cold like an ice cube,
Nothin’ – gonna grow when you cool it,
Split the bug up, slap it on a GeneChip,
Will it bind the probe? Yo – I can’t guess
Turn off the lights, it’ll fluoresce
This lab, bitch, is dope delirium
Knockin’ out genes in some bacterium

Staph, Pseudomonas, E.coli
Layin’ the pain on a mutant fruit fly
Phage, suckers kill bacteria
Got RNA genomes so don’t let em near ya
Love it or leave it, it ain’t DNA,
But does show up on a microarray,
If you got a genome, yo, fantastic,
Check SWISSPROT while you waitin’ for your BLAST hit

Lyse, lyse baby, split your cells
Lyse, lyse baby, split your cells

Lyse, lyse baby, split your cells
Lyse, lyse baby, split your cells

My transposon is jumpin’
Lands in a gene, no sodium pumpin’
Channels all there, so yo, still viable
Doin’ it again, data unreliable
Nature? That plot’s like a hemorrhoid
You’d be lucky to publish a tabloid
I’m evil, like a tricked-out plasmid,
Transformin’ just to do two-hybrid
Shakin’: 37.0
Get some LB down so my bugs can grow

Pipette an aliquot, prep an OD plot
Did it express? Time for a Northern blot
Spilled some, where’s the KimWipes
Hope P32 don’t show up in test swipes
This bug is dead Yo – so I brought in new DNA – lac expression

Your ‘tides are hot cause you want some sequence
Runnin’ a gel just to get the frequence
Jealous – cause I express with Lac
Step up, bitch, you still use Taq
Protein: interactors or none?
No way to tell till a column is run
Timecourse – do CD well,
Melts in guanine HCl
Native – this thing folds real fast
Stable as hell, like the core is die-cast
Side chain to side chain to backbone and back
Packin’ is tight like an asthma attack
Salt bridges here, yo, do I make it clear
Delta-G, yo, must be severe
If you got a genome, yo, fantastic,
Check SWISSPROT while you waitin’ for your BLAST hit

Lyse, lyse baby, split your cells
Lyse, lyse baby, split your cells

Knockout! Time for some genetics
Invert a gene and then do kinetics
Enzyme, it shows Michaelis-Menten
Call the science guy at CNN
‘Cause your lab had a pyridine spill
The stench that reeks and kills
Double fluorophores? I can like a Rockette
Why crosslink ... when you can just
Do FRET! Titrate the Mg
RNA unravels like a new trainee
So fast, your PI says “damn”
Seizes your data and calls it a scam
Pure up my reagents when its time to do chem,
Expose my brain stem to vitamin M
So you got a grant and now you spastic
Bitch, those bucks don’t mean you scholastic

Lyse, lyse baby, split your cells
Lyse, lyse baby, split your cells

Yo man – Let’s get outta here. Cells to the shaker.

© Michael Seringhaus 2001-2006.

 

© 2002-2008